Myoplasmic Ca2+ concentration during exertional rhabdomyolysis.

Abstract

Exertional rhabdomyolysis can destroy muscle but the pathophysiology is unknown. Using intracellular selective microelectrodes, we found that intracellular Ca2+ concentration ([Ca2+]i) was 1.27 (0.17) mumol/L (median and interquartile range) in skeletal-muscle biopsy specimens from patients with exertional rhabdomyolysis compared with 0.12 (0.01) mumol/L in controls. 3 days treatment with dantrolene, a drug that inhibits Ca2+ release from the sarcoplasmic reticulum, decreased [Ca2+]i to 0.22 (0.05) mumol/L and accelerated patients' recovery. This study demonstrated that exertional rhabdomyolysis is associated with elevated [Ca2+]i, and that dantrolene has a beneficial effect in this syndrome.

• Authors: J R López, B Rojas, M A Gonzalez, A Terzic
• Journal: Lancet (London, England) (Lancet) Vol. 345 Issue 8947 Pg. 424-5 (Feb 18 1995) ISSN: 0140-6736 [Print] England
• PMID: 7853954 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dantrolene
• Calcium

Topics

• Adult
• Biopsy
• Calcium (analysis)
• Dantrolene (therapeutic use)
• Female
• Humans
• Intracellular Fluid (chemistry)
• Male
• Muscle, Skeletal (chemistry)
• Physical Exertion
• Rhabdomyolysis (drug therapy, physiopathology)