[Clofibrate treatment of hyperlipoproteinemia].

Abstract

Clofibrate has cholesterol- and triglyceride-lowering effect. They affect on the various points in the metabolic pathway of lipoproteins. They improve VLDL-synthesis in liver and increase the activity of LPL and hepatic TG lipase. As the results, HDL-cholesterol increases and LDL decreases. Therefore Clofibrate decreases not only plasma triglyceride but cholesterol levels. It has been reported that Clofibrate have a preventive effect on cardiovascular disease. So these agents are useful in the treatment for hyperlipidemic patients with or without atherosclerosis.

• Authors: S Oikawa, H Midorikawa
• Journal: Nihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 52 Issue 12 Pg. 3285-91 (Dec 1994) ISSN: 0047-1852 [Print] Japan
• PMID: 7853724 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Lipoproteins
• Triglycerides
• Cholesterol
• Lipoprotein Lipase
• Clofibrate

Topics

• Cholesterol (metabolism)
• Clofibrate (pharmacology, therapeutic use)
• Humans
• Hyperlipoproteinemias (drug therapy)
• Lipoprotein Lipase (metabolism)
• Lipoproteins (metabolism)
• Liver (metabolism)
• Triglycerides (metabolism)