Abstract | BACKGROUND: METHODS: RESULTS: Although basal and sham feeding stimulated acid outputs were higher in duodenal ulcer patients (2.7 +/- 0.3 and 3.7 +/- 0.3 mEq/h, mean +/- SEM) than in normal subjects (1.6 +/- 0.4 and 2.9 +/- 0.6 mEq/h) and in patients with liver cirrhosis (1.8 +/- 0.4 and 2.1 +/- 0.7 mEq/h), it did not reach statistical significance. Both basal and sham feeding stimulated pepsin outputs were significantly higher in duodenal ulcer patients (11.2 +/- 2.1 and 9.5 +/- 2.2 mg/h) than in normal subjects (2.4 +/- 0.5 and 4.3 +/- 1.2 mg/h) and in patients with liver cirrhosis (3.6 +/- 1.4 and 3.9 +/- 1.2 mg/h) (p < 0.05). The serum gastrin and pepsinogen I concentration in basal and sham feeding conditions demonstrated no statistically significant difference among three groups. CONCLUSIONS: Basal and sham feeding stimulated acid outputs in the Chinese were lower in normal subjects and duodenal ulcer patients as compared with those in the Occidentals. High basal pepsin output may play an important role in the pathogenesis of duodenal ulcers in the Chinese.
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Authors | H J Lin, C L Perng, S D Lee |
Journal | Zhonghua yi xue za zhi = Chinese medical journal; Free China ed
(Zhonghua Yi Xue Za Zhi (Taipei))
Vol. 54
Issue 6
Pg. 389-94
(Dec 1994)
ISSN: 0578-1337 [Print] China (Republic : 1949- ) |
PMID | 7850679
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Analysis of Variance
- Duodenal Ulcer
(physiopathology)
- Eating
- Gastric Acid
(metabolism)
- Humans
- Liver Cirrhosis
(physiopathology)
- Male
- Middle Aged
- Pepsin A
(metabolism)
- Prospective Studies
- Taiwan
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