Cerebral protective effects of VA-045, a novel apovincaminic acid derivative, in mice.

Abstract

The cerebral protective effects of VA-045, a novel apovincaminic acid derivative, were investigated in mice under conditions of normobaric hypoxia, histotoxic anoxia by potassium cyanide (KCN), and complete ischemia. VA-045 and thyrotropin releasing hormone (TRH) showed a significant protective effect on normobaric hypoxia. The duration of action of the protective effect of VA-045 was longer than that of TRH. VA-045 but not TRH significantly prolonged the survival time following administration of KCN. VA-045 and TRH showed a positive effect on complete ischemia, and the duration of the protective effect of VA-045 was longer than that of TRH. Beneficial effects of VA-045 for treating cerebral hypoxia, anoxia and ischemia will be discussed.

• Authors: S Yamada, K Yamaguchi, S Okuyama
• Journal: Research communications in molecular pathology and pharmacology (Res Commun Mol Pathol Pharmacol) Vol. 86 Issue 1 Pg. 83-91 (Oct 1994) ISSN: 1078-0297 [Print] United States
• PMID: 7850259 (Publication Type: Journal Article)

Chemical References

• Vasodilator Agents
• Vinca Alkaloids
• 2-(nitrooxy)ethyl apovincaminate
• Thyrotropin-Releasing Hormone

Topics

• Animals
• Brain Ischemia (drug therapy)
• Dose-Response Relationship, Drug
• Hypoxia (drug therapy)
• Injections, Intravenous
• Male
• Mice
• Mice, Inbred ICR
• Thyrotropin-Releasing Hormone (therapeutic use)
• Vasodilator Agents (therapeutic use)
• Vinca Alkaloids (therapeutic use)