Evaluation of intravenous tenoxicam for postoperative cesarean delivery pain relief. Preliminary report.

Abstract

BACKGROUND AND OBJECTIVES:

To assess safety and efficacy of tenoxicam for postoperative pain relief after cesarean delivery.

METHODS:

Postoperative pain relief, supplemental analgesic requirements, and adverse side effects were evaluated in 80 patients undergoing cesarean delivery. Forty patients received a slow intravenous injection of tenoxicam at a fixed dose of 20 mg (2 mL), immediately before induction of spinal anesthesia with 15 mg (3 mL) of 0.5% hyperbaric bupivacaine. The other 40 patients received 2 mL of saline solution. Newborns were evaluated by means of Apgar score and umbilical cord blood gases.

RESULTS:

There was a significant prolongation of analgesia in the tenoxicam group (365 +/- 91.1 minutes versus 305 +/- 53.2 minutes in control group, P < .001). Supplementary analgesic requirements were significantly decreased by intravenous tenoxicam (1.55 +/- 0.70 versus 2.25 +/- 0.68). Adverse side effects did not differ between groups and few complaints of phlebitis were noted. Apgar scores and blood gas analyses were similar in neonates from both groups.

CONCLUSIONS:

Intravenous tenoxicam is safe and slightly increases the length of postoperative analgesia provided by the local anesthetic. It is effective in decreasing analgesic consumption in cesarean delivery patients.

• Authors: S D Belzarena
• Journal: Regional anesthesia (Reg Anesth) 1994 Nov-Dec Vol. 19 Issue 6 Pg. 408-11 ISSN: 0146-521X [Print] United States
• PMID: 7848951 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piroxicam
• Carbon Dioxide
• Oxygen
• Bupivacaine
• tenoxicam

Topics

• Adult
• Analgesia, Obstetrical
• Anesthesia, Obstetrical
• Anesthesia, Spinal
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, adverse effects)
• Apgar Score
• Bupivacaine (administration & dosage)
• Carbon Dioxide (blood)
• Cesarean Section (adverse effects)
• Drug Evaluation
• Female
• Fetal Blood (chemistry)
• Humans
• Infant, Newborn
• Injections, Intravenous
• Oxygen (blood)
• Pain, Postoperative (prevention & control)
• Piroxicam (administration & dosage, adverse effects, analogs & derivatives)
• Pregnancy
• Premedication
• Time Factors