Abstract | OBJECTIVE: Periodic uterine relaxation in labor relieves the fetus from hypoxia related to sustained contractions. A reduction in intracellular calcium is essential for relaxation. Therefore we aimed to clarify the extrusion mechanisms of intracellular calcium ions in pregnant human myometrium. STUDY DESIGN: RESULTS: CONCLUSION: The presence of the sodium- calcium exchange mechanism and the specific inhibitory effect of magnesium were indicated in human myometrium during pregnancy. These mechanisms might prevent the long tonic contractions, to protect the fetus from hypoxia during pregnancy and parturition.
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Authors | F Morishita, T Kawarabayashi, Y Sakamoto, K Shirakawa |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 172
Issue 1 Pt 1
Pg. 186-95
(Jan 1995)
ISSN: 0002-9378 [Print] United States |
PMID | 7847532
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- Indoles
- Sodium-Calcium Exchanger
- Sodium Dodecyl Sulfate
- Sodium
- dodecyl sulfate
- Calcium-Transporting ATPases
- Magnesium
- Nifedipine
- Potassium
- cyclopiazonic acid
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Topics |
- Calcium-Transporting ATPases
(antagonists & inhibitors)
- Carrier Proteins
(physiology)
- Female
- Humans
- In Vitro Techniques
- Indoles
(pharmacology)
- Isometric Contraction
(drug effects)
- Magnesium
(pharmacology)
- Myometrium
(drug effects)
- Nifedipine
(pharmacology)
- Potassium
(pharmacology)
- Pregnancy
(physiology)
- Sodium
(pharmacology)
- Sodium Dodecyl Sulfate
(pharmacology)
- Sodium-Calcium Exchanger
- Uterine Contraction
(drug effects)
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