The efficacy of the combination of l-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension.

Abstract

BACKGROUND:

In this double-blind prospective trial the efficacy of lowering the intraocular pressure of l-moprolol given alone and in combination with dipivefrin was tested.

METHODS:

Twenty-seven patients with primary open-angle glaucoma or ocular hypertension were randomly assigned to receive twice-daily l-moprolol eye drops or dipivefrin eye drops for 4 weeks; in a second phase of the trial, the combination of the two drugs was administered for 4 weeks.

RESULTS:

The results of this study indicated that l-moprolol and dipivefrin had an equivalent effect in lowering the intraocular pressure. The association of the two drugs caused a further reduction of intraocular pressure which was significant only in the group previously treated with dipivefrin alone.

CONCLUSION:

This trial demonstrated that the combination of l-moprolol and dipivefrin is an effective and safe treatment for elevated intraocular pressure.

• Authors: L Rossetti, P Barbieri, P Velati, E Bujtar, N Orzalesi
• Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (Graefes Arch Clin Exp Ophthalmol) Vol. 232 Issue 11 Pg. 670-4 (Nov 1994) ISSN: 0721-832X [Print] Germany
• PMID: 7843592 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Antagonists
• Ophthalmic Solutions
• Phenoxypropanolamines
• Propanolamines
• dipivefrin
• moprolol
• Epinephrine

Topics

• Adrenergic beta-Antagonists (therapeutic use)
• Adult
• Aged
• Aged, 80 and over
• Double-Blind Method
• Drug Therapy, Combination
• Epinephrine (analogs & derivatives, therapeutic use)
• Female
• Glaucoma, Open-Angle (drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Male
• Middle Aged
• Ocular Hypertension (drug therapy)
• Ophthalmic Solutions
• Phenoxypropanolamines
• Propanolamines (therapeutic use)
• Prospective Studies