Lack of efficacy of low-dose sitostanol therapy as an adjunct to a cholesterol-lowering diet in men with moderate hypercholesterolemia.

Abstract

Plant sterols have been shown to reduce dietary cholesterol absorption and hence, total and low-density-lipoprotein (LDL)-cholesterol concentrations in humans. In this study the cholesterol-lowering effects of dietary supplementation with the hydrogenated plant sterol sitostanol (3 g/d) were tested in 33 men with moderate hypercholesterolemia who were consuming an outpatient diet in which dietary cholesterol was restricted to < 200 mg/d. Sitostanol therapy did not significantly lower LDL cholesterol compared with the diet alone. Similarly, sitostanol therapy in conjunction with a cholesterol-lowering regimen of diet and 8 g cholestyramine did not significantly lower LDL-cholesterol concentrations. Hence, although previous reports have suggested that low-dose sitostanol therapy is an effective means of reducing LDL-cholesterol concentrations, its effectiveness may be attenuated when the diet is low in cholesterol.

• Authors: M A Denke
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 61 Issue 2 Pg. 392-6 (Feb 1995) ISSN: 0002-9165 [Print] United States
• PMID: 7840080 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cholesterol, Dietary
• Sitosterols
• Cholestyramine Resin
• stigmastanol

Topics

• Adult
• Aged
• Cholesterol, Dietary (administration & dosage, blood)
• Cholestyramine Resin (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Drug Therapy, Combination
• Humans
• Hypercholesterolemia (diet therapy)
• Male
• Middle Aged
• Sitosterols (administration & dosage, therapeutic use)