Prediction of amikacin dose requirements in neutropenic patients with haematological disease.

Abstract

This study reports on the use of an easily applied Bayesian forecasting programme (OPT; Clydesoft) to predict amikacin dose requirements in 10 patients with haematological disease and neutropenic fever. OPT-determined dose adjustment achieved therapeutic drug levels for 80% of the peak and 94% of the trough measurements.

• Authors: C S Zent, R Allin, P I Folb
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 83 Issue 11 Pg. 853-4 (Nov 1993) ISSN: 0256-9574 [Print] South Africa
• PMID: 7839219 (Publication Type: Journal Article)

Chemical References

• Amikacin

Topics

• Adolescent
• Adult
• Amikacin (administration & dosage, blood)
• Bayes Theorem
• Female
• Hematologic Diseases (complications)
• Humans
• Male
• Middle Aged
• Neutropenia (complications, drug therapy)