[Single dose toxicity studies of lactitol (NS-4) in mice and rats].

Abstract

The single dose toxicity studies of lactitol, a hepatic encephalopathy drug, were performed in ddY mice and SD rats of both sexes by administering the drug orally, intravenously or subcutaneously. The drug was administered as a single dose followed by a 14-day observation. Oral LD50 values of lactitol were estimated to be between 23 and 30 g/kg in male mice, approximately 30 g/kg in female mice, and more than 30 g/kg in male and female rats. Lethal dose was more than 10 g/kg intravenously and subcutaneously in mice and rats of both sexes. The signs of toxicity in mice and rats observed following the administration of this drug included the following: decreased spontaneous movement [p.o., i.v., s.c.]; diarrhea, oligopnea or prone position, transient decreased body weight [p.o]. There were no treatment-related changes in gross examination. Based on these results, it was found that lactitol had a very low acute toxicity when administered by a single dose method in mice and rats.

• Authors: S Okazaki, K Suwa, Y Hamasu, N Sumi
• Journal: The Journal of toxicological sciences (J Toxicol Sci) Vol. 19 Suppl 3 Pg. 295-9 (Nov 1994) ISSN: 0388-1350 [Print] Japan
• PMID: 7837291 (Publication Type: English Abstract, Journal Article)

Chemical References

• Sugar Alcohols
• lactitol

Topics

• Administration, Oral
• Animals
• Diarrhea (chemically induced)
• Female
• Injections, Intravenous
• Injections, Subcutaneous
• Lethal Dose 50
• Male
• Mice
• Mice, Inbred Strains
• Motor Activity (drug effects)
• Rats
• Rats, Sprague-Dawley
• Sugar Alcohols (administration & dosage, toxicity)
• Weight Loss (drug effects)