Mucocutaneous reactions to gold: a prospective study of 74 patients with rheumatoid arthritis.

Abstract

OBJECTIVE:

To describe causality, morphology, course, and risk factors of mucocutaneous reactions to gold.

METHODS:

A prospective study of 74 patients with rheumatoid arthritis starting with gold thioglucose.

RESULTS:

Thirty-nine patients experienced an episode of gold dermatitis. Sixteen patients continued gold treatment. The estimated treatment withdrawal at 1 year was 26%. The clinical picture was variable and nonspecific. Gold dermatitis was associated with HLA-B35 and disease duration.

CONCLUSION:

Mucocutaneous reactions to gold are nonspecific, therefore a causality assessment is necessary. Incidence is high, but treatment can often be continued with dose reduction and local steroids. The predictive value of risk factors is low.

• Authors: A van Gestel, R Koopman, M Wijnands, L van de Putte, P van Riel
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 21 Issue 10 Pg. 1814-9 (Oct 1994) ISSN: 0315-162X [Print] Canada
• PMID: 7837143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-B35 Antigen
• Aurothioglucose

Topics

• Adolescent
• Adult
• Aged
• Arthritis, Rheumatoid (drug therapy, epidemiology)
• Aurothioglucose (adverse effects, therapeutic use)
• Biopsy
• Drug Eruptions (epidemiology, immunology, pathology)
• Female
• HLA-B35 Antigen (analysis)
• Humans
• Incidence
• Male
• Middle Aged
• Predictive Value of Tests
• Prospective Studies
• Risk Factors
• Skin (immunology, pathology)