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Results of a prospective randomized trial of botulinum toxin therapy in acute unilateral sixth nerve palsy.

Abstract
Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied.
AuthorsJ Lee, S Harris, J Cohen, K Cooper, C MacEwen, S Jones
JournalJournal of pediatric ophthalmology and strabismus (J Pediatr Ophthalmol Strabismus) 1994 Sep-Oct Vol. 31 Issue 5 Pg. 283-6 ISSN: 0191-3913 [Print] United States
PMID7837013 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Botulinum Toxins
Topics
  • Abducens Nerve
  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Botulinum Toxins (therapeutic use)
  • Cranial Nerve Diseases (drug therapy)
  • Eye Movements
  • Female
  • Follow-Up Studies
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Paralysis (drug therapy)
  • Prognosis
  • Prospective Studies
  • Vision, Binocular

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