Abstract |
Forty-seven patients entered a prospective randomized trial to assess the effect of early botulinum neurotoxin A treatment to the ipsilateral antagonist medial rectus on the ultimate recovery rate of acute unilateral sixth nerve palsy. Twenty-two patients received injections and 25 acted as controls. The overall etiologies were microvascular (72.3%), unknown (17%), multiple sclerosis (6%), and one case each of central nervous system (CNS) sarcoidosis and basilar artery ectasia. Eighty-three percent of the patients entered the trial within 2 weeks of the onset of symptoms and 95.7% within 3 weeks. The controls had a final recovery rate of 20/25 (80%), and the injected group had a final recovery rate of 19/22 (86%). No serious side effects were encountered. We conclude that there is no evidence for a prophylactic effect of botulinum toxin in the group that we have studied.
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Authors | J Lee, S Harris, J Cohen, K Cooper, C MacEwen, S Jones |
Journal | Journal of pediatric ophthalmology and strabismus
(J Pediatr Ophthalmol Strabismus)
1994 Sep-Oct
Vol. 31
Issue 5
Pg. 283-6
ISSN: 0191-3913 [Print] United States |
PMID | 7837013
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Abducens Nerve
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Botulinum Toxins
(therapeutic use)
- Cranial Nerve Diseases
(drug therapy)
- Eye Movements
- Female
- Follow-Up Studies
- Humans
- Injections
- Male
- Middle Aged
- Paralysis
(drug therapy)
- Prognosis
- Prospective Studies
- Vision, Binocular
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