Abstract |
1. In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the pressor response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3. 8-OH DPAT and RU 24969 produced no significant tachycardia, while DOI neither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metoclopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.
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Authors | M K Krstić, Z S Katusić |
Journal | General pharmacology
(Gen Pharmacol)
Vol. 25
Issue 5
Pg. 917-21
(Sep 1994)
ISSN: 0306-3623 [Print] England |
PMID | 7835637
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ergolines
- Receptors, Serotonin
- Serotonin
- Methiothepin
- 8-Hydroxy-2-(di-n-propylamino)tetralin
- Ketanserin
- mesulergine
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Topics |
- 8-Hydroxy-2-(di-n-propylamino)tetralin
(pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Ergolines
(pharmacology)
- Female
- Heart Rate
(drug effects)
- Ketanserin
(pharmacology)
- Male
- Methiothepin
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Serotonin
(drug effects, physiology)
- Serotonin
(pharmacology)
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