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Further evidence that the tachycardiac response to 5-hydroxytryptamine in rats is not mediated via typical 5-HT2 receptors.

Abstract
1. In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the pressor response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3. 8-OH DPAT and RU 24969 produced no significant tachycardia, while DOI neither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metoclopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.
AuthorsM K Krstić, Z S Katusić
JournalGeneral pharmacology (Gen Pharmacol) Vol. 25 Issue 5 Pg. 917-21 (Sep 1994) ISSN: 0306-3623 [Print] England
PMID7835637 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ergolines
  • Receptors, Serotonin
  • Serotonin
  • Methiothepin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Ketanserin
  • mesulergine
Topics
  • 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
  • Animals
  • Blood Pressure (drug effects)
  • Ergolines (pharmacology)
  • Female
  • Heart Rate (drug effects)
  • Ketanserin (pharmacology)
  • Male
  • Methiothepin (pharmacology)
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin (drug effects, physiology)
  • Serotonin (pharmacology)

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