Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach progressing to overt B cell malignancy.

Abstract

A 70 year old man, who underwent subtotal gastrectomy under the diagnosis of reactive lymphoid hyperplasia 6 years earlier, suffered from diffuse large-cell-type B cell lymphoma in the remnant stomach. Retrospectively reviewed, the initial lesion was consistent with mucosa-associated lymphoid tissue (MALT) lymphoma, a low-grade B cell malignancy, based upon histologic, cytologic and immunohistochemical features. Both the initial and recurrent tumors revealed the phenotypes of mantle zone cells, DBA44-positive. It is noteworthy that the overt lymphoma cells retained the capacity for inducing germinal center-like nodules consisting of LN1 and DNA7-positive cells even in the invading site. The diagnosis of reactive lymphoid hyperplasia of the stomach should be made after careful exclusion of the possibility of MALT lymphoma.

• Authors: S Umemura, X Tang, H Aihara, Y Tsutsumi
• Journal: Pathology international (Pathol Int) 1994 Oct-Nov Vol. 44 Issue 10-11 Pg. 808-14 ISSN: 1320-5463 [Print] Australia
• PMID: 7834084 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Cell Transformation, Neoplastic (pathology)
• Humans
• Lymphoma, B-Cell (pathology)
• Lymphoma, B-Cell, Marginal Zone (pathology)
• Male
• Stomach Neoplasms (pathology)