Abstract |
Many laboratory and clinical studies suggest that oxygen radical formation and resultant cell damage contribute to CNS injury following stroke and neurotrauma. Accordingly, antioxidants represent a viable therapeutic approach for management of CNS oxidative damage. Recently, several investigators have reported that the spin trap PBN protects against stroked-induced damage and reduces aging-associated neurological deficits. We have prepared and tested a cyclic analog of PBN, MDL 101,002, in a number of in vitro and in vivo assays designed to assess its neuroprotective properties. MDL 101,002 was found to be an effective . OH trap, to inhibit lipid peroxidation, and to decrease infarct size in a gerbil model of stroke. These results further indicate that oxidative damage arising from stroke contributes to infarct formation, and that spin traps are effective in ameliorating ischemia and reperfusion-induced CNS injury.
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Authors | C E Thomas, J M Carney, R C Bernotas, D A Hay, A A Carr |
Journal | Annals of the New York Academy of Sciences
(Ann N Y Acad Sci)
Vol. 738
Pg. 243-9
(Nov 17 1994)
ISSN: 0077-8923 [Print] United States |
PMID | 7832433
(Publication Type: Journal Article)
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Chemical References |
- 3,4-dihydro-3,3-dimethylisoquinoline-N-oxide
- Cyclic N-Oxides
- Isoquinolines
- Nitrogen Oxides
- Spin Labels
- Hydroxyl Radical
- phenyl-N-tert-butylnitrone
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Topics |
- Animals
- Brain
(metabolism, pathology, physiopathology)
- Cerebral Infarction
(pathology, physiopathology)
- Cyclic N-Oxides
- Electron Spin Resonance Spectroscopy
- Gerbillinae
- Hydroxyl Radical
(analysis, metabolism)
- Ischemic Attack, Transient
(pathology, physiopathology)
- Isoquinolines
(pharmacology)
- Lipid Peroxidation
(drug effects)
- Motor Activity
- Neurons
(pathology)
- Nitrogen Oxides
(pharmacology)
- Reperfusion
- Spin Labels
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