Bacteriostatic and bactericidal activities of paromomycin against Mycobacterium avium complex isolates.

Abstract

The MICs and MBCs of paromomycin for 32 Mycobacterium avium complex (MAC) strains isolated from patients with the acquired immunodeficiency syndrome were determined by a radiometric broth dilution method. The MICs for the majority of strains were either 8 or 16 mg/L and the MBCs were four- to eight-fold higher. Paromomycin merits further evaluation as oral prophylaxis against disseminated MAC infection.

• Authors: C Piersimoni, S Bornigia, G De Sio, G Scalise
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 34 Issue 3 Pg. 421-4 (Sep 1994) ISSN: 0305-7453 [Print] England
• PMID: 7829417 (Publication Type: Journal Article)

Chemical References

• Paromomycin

Topics

• Acquired Immunodeficiency Syndrome (microbiology)
• Humans
• Microbial Sensitivity Tests
• Mycobacterium avium Complex (drug effects, growth & development, isolation & purification)
• Paromomycin (pharmacology)