[The mechanism(s) of alpha-(aminoethyl)-gamma-butyrolactone. In vivo studies in mice].

Abstract

This paper describes the synthesis of alpha-(dimethylaminoethyl)-gamma, gamma-diphenyl-gamma-butyrolactone 4. The study of convulsions induced, on mice, by this compound could show the existence of antiGABAergic and cholinergic action components, but, unlike the homologous alpha- (dialkylaminomethil)-gamma-butyrolactones (with one -CH2- less on the aminoalkyl chain), no antiglycinergic component was detected. The effects of atropine on the aminolactone 4 induced convulsions (antagonism 5mn and synergy 30 mn after atropine) could suggest an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the aminolactone 4.

• Authors: N Kolocouris, G Fytas, G B Foscolos, I Kalliteraki, A Vamvakides
• Journal: Bollettino chimico farmaceutico (Boll Chim Farm) Vol. 133 Issue 8 Pg. 516-20 (Sep 1994) ISSN: 0006-6648 [Print] Italy
• Vernacular Title: Les mechanisme(s) d'une a-(aminoéthyl)-gamma butyrolactone. Etudes in vivo chez la souris.
• PMID: 7826586 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Convulsants
• Atropine
• 4-Butyrolactone

Topics

• 4-Butyrolactone (analogs & derivatives, chemical synthesis, pharmacology)
• Animals
• Atropine (pharmacology)
• Convulsants (chemical synthesis, pharmacology)
• Male
• Mice