Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity.

Abstract

OBJECTIVE:

To investigate if the increased concentrations of stromelysin (MMP-3) found in the synovial fluid (SF) of patients with various arthritides reflect the concentrations in the circulation.

METHODS:

Using a double antibody ELISA, we have measured proMMP-3 concentrations in sera from these patient groups and in others with a heightened acute phase response (APR) as a result of multiple organ failure.

RESULTS:

The median serum concentration of proMMP-3 was increased by up to ninefold in the inflammatory arthritides, but not in osteoarthritis or in patients with a heightened APR resulting from a non-chronic inflammatory condition.

CONCLUSION:

In chronic inflammatory diseases such as rheumatoid arthritis, serum proMMP-3 may prove to be a more specific indicator of monokine activity than currently available serum markers.

• Authors: D J Taylor, N T Cheung, P T Dawes
• Journal: Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 53 Issue 11 Pg. 768-72 (Nov 1994) ISSN: 0003-4967 [Print] England
• PMID: 7826140 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Enzyme Precursors
• C-Reactive Protein
• Metalloendopeptidases
• prostromelysin

Topics

• Acute-Phase Reaction (blood)
• Adult
• Arthritis (blood, metabolism)
• Arthritis, Rheumatoid (blood)
• Biomarkers (blood)
• C-Reactive Protein (analysis)
• Enzyme Precursors (analysis, blood)
• Enzyme-Linked Immunosorbent Assay (methods)
• Female
• Humans
• Male
• Metalloendopeptidases (analysis, blood)
• Middle Aged
• Osteoarthritis (blood)
• Spondylitis, Ankylosing (blood)
• Synovial Fluid (chemistry)