The central effects of moxonidine on intraocular pressure and its antagonism by L-659, 066 and L-657, 743 in the rabbit.

Abstract

1) The imidazoline, moxonidine (MOX), injected icvt into the anterior lateral ventricle of NZW rabbits induced ocular hypotension (> 7.0 mmHg) that persisted for two hrs. 2) L-659, 066 injected i.v. or icvt inhibited MOX-induced ocular hypotension, significantly. 3) L-657, 743, injected icvt at 100-fold lower concentration than icvt L-659, 066, significantly inhibited MOX-induced ocular hypotension. 4) Alpha-2-adrenoceptors, located in the CNS, play a role in MOX-induced ocular hypotension, as evidenced by the ability of the relatively selective alpha-2 antagonists, L-659, 066 and L-657, 743 to inhibit icvt MOX-induced ocular hypotension.

• Authors: W R Campbell, D E Potter
• Journal: Progress in neuro-psychopharmacology & biological psychiatry (Prog Neuropsychopharmacol Biol Psychiatry) Vol. 18 Issue 6 Pg. 1051-61 (Oct 1994) ISSN: 0278-5846 [Print] England
• PMID: 7824759 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists
• Antidepressive Agents
• Imidazoles
• Quinolizines
• L 657743
• vatinoxan
• moxonidine

Topics

• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists (administration & dosage, pharmacology)
• Animals
• Antidepressive Agents (administration & dosage, antagonists & inhibitors, pharmacology)
• Imidazoles (administration & dosage, antagonists & inhibitors, pharmacology)
• Injections, Intravenous
• Injections, Intraventricular
• Intraocular Pressure (drug effects)
• Male
• Pupil (drug effects)
• Quinolizines (administration & dosage, pharmacology)
• Rabbits