[Antimicrobial action of the combination sulfamoxole/trimethoprim in vivo (author's transl)].

Abstract

The experimental infections of the mouse by gram-positive and gram-negative germs are effectively treated with the combination of N1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) (CN 3123, Nevin, Supristol). The potentiating effect of both substances is demonstrated by the calculated index of the synergistic effect. The therapeutic efficacy of the combination sulfamoxole/trimethoprim is proved by two models of experimental urinary infections in the rat. In the malaria of chicken and mice a notable therapeutic success is observed.

• Authors: F W Kohlmann, H Sous
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 26 Issue 42 Pg. 618-20 ( 1976) ISSN: 0004-4172 [Print] Germany
• Vernacular Title: Antimikrobielle Wirkung der Kombination Sulfamoxol/Trimethoprim (CN 3123) in vivo
• PMID: 782473 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Trimethoprim
• Sulfamoxole

Topics

• Animals
• Bacterial Infections (drug therapy)
• Chickens
• Cystitis (drug therapy)
• Drug Combinations
• Female
• Malaria (drug therapy)
• Malaria, Avian (drug therapy)
• Male
• Mice
• Plasmodium berghei
• Pyelonephritis (drug therapy)
• Rats
• Sulfamoxole (therapeutic use)
• Trimethoprim (therapeutic use)