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Serotonin 5-HT3 antagonists fail to affect ethanol self-administration of rats.

Abstract
Five Long-Evans hooded rats were trained to lever press according to fixed-ratio 5 reinforcement schedules for 0.06 ml dipper deliveries of 8% w/v ethanol during daily (M-F) 0.5-h experimental sessions. After ethanol self-administration was established, doses of the serotonin 5-HT3 antagonists, ondansetron (0.03-3.0 mg/kg), granisetron (0.01-1.0 mg/kg), and SC-51296 (0.1-10.0 mg/kg) were administered prior to ethanol sessions to determine their effects on ethanol self-administration. None of the doses of the antagonists had significant effects on numbers of obtained ethanol deliveries. Subsequently, each antagonist (ondansetron, 0.1 mg/kg; granisetron, 0.3 mg/kg; SC-51296, 0.1 mg/kg) was administered b.i.d. for five consecutive daily sessions. During none of these chronic tests with the 5-HT3 antagonists were there significant main effects of drug administration. Overall, these results do not support the hypothesis that the serotonin 5-HT3 antagonists would have robust therapeutic efficacy in the treatment of alcoholism.
AuthorsP M Beardsley, O T Lopez, G Gullikson, D Flynn
JournalAlcohol (Fayetteville, N.Y.) (Alcohol) 1994 Sep-Oct Vol. 11 Issue 5 Pg. 389-95 ISSN: 0741-8329 [Print] United States
PMID7818797 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Indazoles
  • SC 51296
  • Serotonin Antagonists
  • Ethanol
  • Ondansetron
  • Granisetron
Topics
  • Alcoholism (drug therapy)
  • Animals
  • Ethanol (administration & dosage)
  • Granisetron (administration & dosage, pharmacology)
  • Indazoles (administration & dosage, pharmacology)
  • Male
  • Ondansetron (administration & dosage, pharmacology)
  • Rats
  • Reinforcement, Psychology
  • Self Administration
  • Serotonin Antagonists (pharmacology)

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