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Retroperitoneal fibrosis treated with methylprednisolon pulse and disease-modifying antirheumatic drugs.

Abstract
The conventional treatment of patients with ureteric obstruction due to retroperitoneal fibrosis (RF) is surgery in combination with long-term corticosteroids. This report describes 11 cases of RF with ureteric obstruction treated with methyl-prednisolon pulse therapy (MPPT) in combination with azathioprine or penicillamine following initial insertion of ureteral stents. The medial treatment suggested was successful in 7 patients, but only moderately effective in the last 4 patients. This principle of non-operative management of RF has not been previously reported.
AuthorsM Harreby, T Bilde, P Helin, H H Meyhoff, H Vinterberg, V A Nielsen
JournalScandinavian journal of urology and nephrology (Scand J Urol Nephrol) Vol. 28 Issue 3 Pg. 237-42 (Sep 1994) ISSN: 0036-5599 [Print] England
PMID7817165 (Publication Type: Journal Article)
Chemical References
  • Penicillamine
  • Azathioprine
  • Methylprednisolone
Topics
  • Adult
  • Azathioprine (administration & dosage, therapeutic use)
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Methylprednisolone (administration & dosage, therapeutic use)
  • Nephrostomy, Percutaneous
  • Penicillamine (administration & dosage, therapeutic use)
  • Radiography
  • Retroperitoneal Fibrosis (complications, diagnostic imaging, drug therapy)
  • Stents
  • Time Factors
  • Treatment Outcome
  • Ureteral Obstruction (etiology, therapy)

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