Abstract |
The effectiveness of topical terbinafine (TBF) to tinea pedis was evaluated an animal model in which guinea pigs were experimentally infected through their planta pedis with Trichophyton mentagrophytes, then a 1% TBF or butenafine (BTF) cream was administered topically once daily for 4 consecutive weeks. The therapeutic efficacy was assessed on the basis of recovery of fungal cultures from the planta pedis. The cured guinea pigs were reared in a clean environment that protected the animals from reinfection. The dermal tissues were cultured 2, 4, and 8 weeks post-treatment to examine for relapse of tinea. Complete cure was achieved after 4 weeks of administration of TBF or BTF cream. In animals receiving 4 weeks of treatment with TBF, relapse was not observed up to 8 weeks after the termination of treatment. In animals treated with BTF for 4 weeks, while no relapse occurred 4 weeks after cessation of the treatment, relapse was detected in 2 out of 10 feet at 8 weeks after the termination of treatment. These results suggest that topical TBF is effective in curing the infection and in preventing relapse in a guinea pig model of tinea pedis.
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Authors | K Uchida, M Kudoh, H Yamaguchi |
Journal | The Japanese journal of antibiotics
(Jpn J Antibiot)
Vol. 47
Issue 10
Pg. 1407-12
(Oct 1994)
ISSN: 0368-2781 [Print] Japan |
PMID | 7807700
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antifungal Agents
- Benzylamines
- Naphthalenes
- butenafine
- Terbinafine
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Topics |
- Administration, Topical
- Animals
- Antifungal Agents
(administration & dosage)
- Benzylamines
(administration & dosage, therapeutic use)
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Female
- Guinea Pigs
- Naphthalenes
(administration & dosage, therapeutic use)
- Recurrence
- Terbinafine
- Tinea Pedis
(drug therapy, microbiology, prevention & control)
- Trichophyton
(drug effects, isolation & purification)
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