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[A study on effectiveness of treatment and prevention of relapse using topical administration of terbinafine in a guinea pig model for tinea pedis].

Abstract
The effectiveness of topical terbinafine (TBF) to tinea pedis was evaluated an animal model in which guinea pigs were experimentally infected through their planta pedis with Trichophyton mentagrophytes, then a 1% TBF or butenafine (BTF) cream was administered topically once daily for 4 consecutive weeks. The therapeutic efficacy was assessed on the basis of recovery of fungal cultures from the planta pedis. The cured guinea pigs were reared in a clean environment that protected the animals from reinfection. The dermal tissues were cultured 2, 4, and 8 weeks post-treatment to examine for relapse of tinea. Complete cure was achieved after 4 weeks of administration of TBF or BTF cream. In animals receiving 4 weeks of treatment with TBF, relapse was not observed up to 8 weeks after the termination of treatment. In animals treated with BTF for 4 weeks, while no relapse occurred 4 weeks after cessation of the treatment, relapse was detected in 2 out of 10 feet at 8 weeks after the termination of treatment. These results suggest that topical TBF is effective in curing the infection and in preventing relapse in a guinea pig model of tinea pedis.
AuthorsK Uchida, M Kudoh, H Yamaguchi
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 47 Issue 10 Pg. 1407-12 (Oct 1994) ISSN: 0368-2781 [Print] Japan
PMID7807700 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antifungal Agents
  • Benzylamines
  • Naphthalenes
  • butenafine
  • Terbinafine
Topics
  • Administration, Topical
  • Animals
  • Antifungal Agents (administration & dosage)
  • Benzylamines (administration & dosage, therapeutic use)
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Female
  • Guinea Pigs
  • Naphthalenes (administration & dosage, therapeutic use)
  • Recurrence
  • Terbinafine
  • Tinea Pedis (drug therapy, microbiology, prevention & control)
  • Trichophyton (drug effects, isolation & purification)

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