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Coadministration of fluvoxamine increases serum concentrations of haloperidol.

Abstract
Four patients with chronic schizophrenia were treated with a combination of fluvoxamine, haloperidol, and benztropine. The combination significantly impaired performance on tests of delayed recall memory and attentional function. Haloperidol concentrations in serum were monitored in three patients and were robustly elevated by fluvoxamine.
AuthorsD G Daniel, C Randolph, G Jaskiw, S Handel, T Williams, A Abi-Dargham, S Shoaf, M Egan, A Elkashef, S Liboff
JournalJournal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 14 Issue 5 Pg. 340-3 (Oct 1994) ISSN: 0271-0749 [Print] United States
PMID7806690 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Benztropine
  • Haloperidol
  • Fluvoxamine
Topics
  • Adult
  • Benztropine (administration & dosage, adverse effects, pharmacokinetics)
  • Chronic Disease
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Fluvoxamine (administration & dosage, adverse effects, pharmacokinetics)
  • Haloperidol (administration & dosage, adverse effects, pharmacokinetics)
  • Humans
  • Male
  • Middle Aged
  • Neurologic Examination (drug effects)
  • Psychiatric Status Rating Scales
  • Schizophrenia (blood, drug therapy)
  • Schizophrenic Psychology

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