Thrombotic thrombocytopenic purpura: a rare late complication of allogeneic bone marrow transplantation.

Abstract

Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) usually occurs in a setting of systemic infection or graft-versus-host reaction during the first weeks following transplant. We report a case of fatal TTP that developed eight months after allogeneic bone marrow transplantation (BMT) without any evident association with other transplantation-related complications. Conditioning chemotherapy could have induced the disorder by causing damage to the vascular endothelium. The removal of immunosuppression, including cessation of cyclosporin A (CyA), may have precipitated the disease.

• Authors: G Pucci, M Martino, F Morabito, P Iacopino, W Arcese, A P Iori, V T Lombardo, A L'Abbate, M Santostefano, F Nobile
• Journal: Haematologica (Haematologica) 1994 Jul-Aug Vol. 79 Issue 4 Pg. 371-3 ISSN: 0390-6078 [Print] Italy
• PMID: 7806094 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation (adverse effects)
• Fatal Outcome
• Female
• Humans
• Purpura, Thrombotic Thrombocytopenic (etiology)
• Transplantation, Homologous