Uterine myxoid leiomyosarcoma and CYVADIC-etoposide therapy.

Abstract

OBJECTIVES:

To conduct a pathological characterization of rare uterine myxoid leiomyosarcoma (MLS) and establish an effective chemotherapy for metastasis after hysterectomy.

METHODS:

Histological and immunohistochemical methods were used to characterize the type of uterine MLS in a 39-year-old female. For multiple lung metastases found 3 months after operation, CYVADIC (400 mg cyclophosphamide, 1 mg vincristine, 50 mg epirubicin and 400 mg dacarbazine per body for one course) and oral etoposide (50 mg/body per day for 2 weeks) were applied.

RESULTS:

The rapidly enlarging uterine tumors exhibited gelatinous cut surfaces, a high count of 30 mitotic cells per 10 hpf and mucinous stroma, indicating a rare high-mitotic type of uterine MLS. The two-course CYVADIC-etoposide therapy was effective for disseminated pulmonary metastases.

CONCLUSION:

The present MLS was a rare high-mitotic type. CYVADIC-etoposide was an optional effective chemotherapy for lung metastasis in this case.

• Authors: H Fukunishi, N Yukimura, S Takeuchi, S Kitazawa
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 46 Issue 3 Pg. 321-4 (Sep 1994) ISSN: 0020-7292 [Print] United States
• PMID: 7806003 (Publication Type: Case Reports, Journal Article)

Chemical References

• Epirubicin
• Vincristine
• Etoposide
• Dacarbazine
• Cyclophosphamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Dacarbazine (administration & dosage)
• Epirubicin (administration & dosage)
• Etoposide (administration & dosage)
• Fatal Outcome
• Female
• Humans
• Hysterectomy
• Immunohistochemistry
• Leiomyosarcoma (diagnosis, drug therapy, secondary)
• Lung Neoplasms (diagnosis, drug therapy, secondary)
• Mitotic Index
• Treatment Outcome
• Uterine Neoplasms (pathology, surgery)
• Vincristine (administration & dosage)