HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[The mechanism producing nausea during ventriculography performed with ioxaglate: the implications of a randomized study].

AbstractINTRODUCTION:
The mechanism of ioxaglate-induced nausea has not been fully elucidated. Recent studies have demonstrated that serotonin is one of the principal neurotransmitters of emesis in humans. On the other hand, the greater capacity of ioxaglate to stimulate vomiting has been ascribed to its great ability to inhibit cholinesterase.
METHODS:
To determine if oral metoclopramide (a serotonin receptor-blocker) is effective in the prophylaxis of ioxaglate-induced nausea during left ventriculography, 637 of 711 consecutive eligible patients were included in a prospective study. Patients were randomized to receive, 60-90 minutes before the procedure, either diazepam 10 mg p.o. (control group [n = 315]) or diazepam 10 mg p.o. plus metoclopramide 10 mg p.o. (metoclopramide group [n = 322]).
RESULTS:
The two randomized groups were similar in relation to baseline clinical and hemodynamic characteristics. Nausea was documented in 103 patients (16.1%) with similar incidence in the two groups (control group: 16.8%, metoclopramide group: 15.5%; p = NS). Nausea duration was also similar (56 +/- 63 s vs 52 +/- 63 s; p = NS). When patients with and without nausea were compared, the following variables showed a significant difference between the two groups: male gender (86% vs 76%; p < 0.05), age (53 +/- 10 yrs vs 56 +/- 9 yrs; p < 0.05) and body surface area (1.84 +/- 0.2 m2 vs 1.78 +/- 0.1 m2; p < 0.01). Stepwise multiple regression analysis identified low age (p = 0.02) and male gender (p = 0.06) as independent predictors of nausea. The incidence of nausea was 24% in males < or = 45 yrs vs 9% in females > 45 yrs (p < 0.05).
CONCLUSIONS:
Prophylaxis with oral metoclopramide did not reduce the incidence of ioxaglate-induced nausea during left ventriculography. This data do not support a role of serotonin in the production of nausea by ioxaglate. Low age an male gender are independent predictors of nausea apparition during left ventriculography. A cholinergic mechanism is probably involved in the capacity of ioxaglate to stimulate vomiting.
AuthorsJ A Gómez-Hospital, A Cequier, J Sala, J Mauri, C Catarino, M Sabaté, J E Barthe, L Valerio, F Jara, E Esplugas
JournalRevista espanola de cardiologia (Rev Esp Cardiol) Vol. 47 Issue 11 Pg. 729-34 (Nov 1994) ISSN: 0300-8932 [Print] Spain
Vernacular TitleMecanismo de producción de las náuseas duŕante la ventriculografía realizada con ioxaglato: implicaciones de un estudio randomizado.
PMID7800902 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • Metoclopramide
  • Diazepam
  • Ioxaglic Acid
Topics
  • Administration, Oral
  • Diazepam (therapeutic use)
  • Drug Therapy, Combination
  • Electrocardiography (drug effects)
  • Female
  • Gated Blood-Pool Imaging
  • Hemodynamics (drug effects)
  • Humans
  • Ioxaglic Acid (adverse effects)
  • Male
  • Metoclopramide (therapeutic use)
  • Middle Aged
  • Nausea (chemically induced, prevention & control)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: