Abstract |
Antioxidative effects of the nitrovasodilator nicorandil (SG-75) and denitrated SG-75 (SG-86) were examined in vivo and in vitro. When the isolated rat liver was reperfused with Krebs-Henseleit solution after a 90-min ischemia, microsomal GSH S- transferase activity was increased significantly by oxidative modification of the sulfhydryl group of the enzyme. The increase in the transferase activity after ischemia/reperfusion was depressed by SG-75 but not by SG-86. Furthermore, only SG-75 significantly inhibited lipid peroxidation and the activation of microsomal GSH S- transferase induced by hydrogen peroxide treatment of liver microsomes. These data indicate that SG-75 has an antioxidative action and the nitro group of SG-75 may play a critical role for this action.
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Authors | A Naito, Y Aniya, M Sakanashi |
Journal | Japanese journal of pharmacology
(Jpn J Pharmacol)
Vol. 65
Issue 3
Pg. 209-13
(Jul 1994)
ISSN: 0021-5198 [Print] Japan |
PMID | 7799521
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antioxidants
- Propanolamines
- Vasodilator Agents
- Niacinamide
- Nicorandil
- N-(2-hydroxyethyl)nicotinamide
- Glutathione Transferase
- nipradilol
- Nitroglycerin
- Isosorbide Dinitrate
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Dose-Response Relationship, Drug
- Enzyme Activation
(drug effects)
- Glutathione Transferase
(metabolism)
- Isosorbide Dinitrate
(pharmacology)
- Lipid Peroxidation
(drug effects)
- Male
- Microsomes, Liver
(drug effects, enzymology)
- Niacinamide
(analogs & derivatives, pharmacology, therapeutic use)
- Nicorandil
- Nitroglycerin
(pharmacology)
- Oxidation-Reduction
(drug effects)
- Propanolamines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Reperfusion Injury
(chemically induced, drug therapy, enzymology)
- Structure-Activity Relationship
- Sympathetic Nervous System
(drug effects)
- Vasodilator Agents
(pharmacology, therapeutic use)
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