Trachyspic acid, a new metabolite produced by Talaromyces trachyspermus, that inhibits tumor cell heparanase: taxonomy of the producing strain, fermentation, isolation, structural elucidation, and biological activity.

Abstract	Trachyspic acid, a new metabolite that inhibited heparanase, was isolated from the culture broth of Talaromyces trachyspermus SANK 12191. Its structure was deduced from NMR spectral analyses and chemical reactions as a tricarboxylic acid derivative containing a spiroketal. The IC50 value of trachyspic acid against heparanase was 36 microM.
Authors	H Shiozawa, M Takahashi, T Takatsu, T Kinoshita, K Tanzawa, T Hosoya, K Furuya, S Takahashi, K Furihata, H Seto
Journal	The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 48 Issue 5 Pg. 357-62 (May 1995) ISSN: 0021-8820 [Print] England
PMID	7797435 (Publication Type: Journal Article)
Chemical References	Enzyme Inhibitors Spiro Compounds trachyspic acid Glycoside Hydrolases heparanase Glucuronidase
Topics	Ascomycota (metabolism) Enzyme Inhibitors (chemistry, isolation & purification, pharmacology) Fermentation Glucuronidase Glycoside Hydrolases (antagonists & inhibitors) Magnetic Resonance Spectroscopy Melanoma, Experimental (enzymology) Spiro Compounds (chemistry, isolation & purification, pharmacology) Structure-Activity Relationship

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