Effects of cytogenin, a novel anti-arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats.

Abstract

The anti-arthritic effects of cytogenin (8-hydroxy-3-hydroxymethyl-6- methoxyisocoumarin) on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats were examined. Prophylactic treatment with cytogenin (30, 100 mg/kg) had a potent inhibitory effect on type II collagen-induced arthritis. Prophylactic or therapeutic treatment with cytogenin (10, 30 and 100 mg/kg) also had a potent inhibitory effect on adjuvant arthritis. In contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), cytogenin (10, 30 and 100 mg/kg) had neither an anti-inflammatory effect on carrageenan-induced paw oedema in rats nor an analgesic effect on acetic acid-induced writhing in mice. These results suggest that the mode of the anti-arthritic action of cytogenin is different from that of NSAIDs and that cytogenin may become a useful drug for the treatment of rheumatoid arthritis.

• Authors: S Hirano, K Wakazono, N Agata, T Mase, R Yamamoto, M Matsufuji, N Sakata, H Iguchi, H Tone, M Ishizuka
• Journal: International journal of tissue reactions (Int J Tissue React) Vol. 16 Issue 4 Pg. 155-62 ( 1994) ISSN: 0250-0868 [Print] Switzerland
• PMID: 7797401 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antirheumatic Agents
• Coumarins
• Isocoumarins
• cytogenin
• Carrageenan
• Collagen

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antirheumatic Agents (therapeutic use)
• Arthritis (chemically induced, drug therapy)
• Arthritis, Experimental (drug therapy)
• Carrageenan
• Collagen
• Coumarins (therapeutic use)
• Edema (chemically induced, drug therapy)
• Female
• Isocoumarins
• Male
• Mice
• Mice, Inbred DBA
• Rats
• Rats, Inbred Lew