[Dynamic observation and significance of autoantibody against ADP/ATP carrier in dilated cardiomyopathy].

Abstract

The presence and dynamic change of autoantibody against ADP/ATP carrier in patients with dilated cardiomyopathy (DCM) was studied by using indirect micro-solid-phase radioimmunoassay. A significant antibody titre was present in 16 of 48 DCM patients and most of them were in early stage of the disease. The titre of anti-ADP/ATP carrier antibody in DCM patients decreased gradually in a follow-up period of three months. The titre of this antibody in the serum from patients with coronary and rheumatic heart disease were within normal limits. Anti-ADP/ATP carrier antibody may play an important role in the pathogenesis, diagnosis and treatment of DCM.

• Authors: W Zhang, Z Liu, D Yang
• Journal: Zhonghua nei ke za zhi (Zhonghua Nei Ke Za Zhi) Vol. 34 Issue 2 Pg. 95-7 (Feb 1995) ISSN: 0578-1426 [Print] China
• PMID: 7796665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantibodies
• CD8 Antigens
• Mitochondrial ADP, ATP Translocases

Topics

• Adult
• Aged
• Autoantibodies (blood)
• CD8 Antigens (immunology)
• Cardiomyopathy, Dilated (diagnosis, immunology)
• Female
• Humans
• Lymphocyte Count
• Male
• Middle Aged
• Mitochondrial ADP, ATP Translocases (immunology)
• Radioimmunoassay