[A case of pulmonary aspergillosis effectively treated with itraconazole. Possible interaction of the antimycotic agent with hydroquinidine].

Abstract

This study describes a case of pulmonary aspergilloma in a neutropenic patient affected with myelodysplastic syndrome. It reports the therapeutic efficacy of itraconazole, emphasizing in particular the possible interaction with quinidine, with QT prolongation--at ECG--disappeared after quinidine withdrawal.

• Authors: V Cruccu, D Pedretti, F Confalonieri
• Journal: La Clinica terapeutica (Clin Ter) Vol. 146 Issue 5 Pg. 383-9 (May 1995) ISSN: 0009-9074 [Print] Italy
• Vernacular Title: Un caso di aspergillosi polmonare trattato efficacemente con itraconazolo. Possibile interferenza dell'antimicotico con la idrochinidina.
• PMID: 7796571 (Publication Type: Journal Article)

Chemical References

• Anti-Arrhythmia Agents
• Antifungal Agents
• Itraconazole
• hydroquinidine
• Quinidine

Topics

• Anti-Arrhythmia Agents (therapeutic use)
• Antifungal Agents (therapeutic use)
• Aspergillosis, Allergic Bronchopulmonary (complications, diagnostic imaging, drug therapy)
• Bradycardia (diagnosis, drug therapy, etiology)
• Drug Interactions
• Electrocardiography
• Itraconazole (therapeutic use)
• Myelodysplastic Syndromes (complications, drug therapy)
• Neutropenia (complications)
• Quinidine (analogs & derivatives, therapeutic use)
• Radiography, Thoracic