Abstract |
The effect of the starch-containing powder BioSorb on wound healing was examined in an immunocompetent and a T cell-deficient animal model. Wounds were tested by tensionometry to give values of resilience, ultimate strength, toughness and extension. Starch significantly decreased the resilience (P < 0.03), ultimate strength (P < 0.004), and toughness (P < 0.006) of wounds in the immunocompetent model but was not shown to affect the healing of wounds in T cell-depleted animals. When the uncontaminated wounds of the two groups were compared, those from T cell-depleted animals were tougher (P < 0.04) and less extensile (P < 0.0002). These results suggest that starch impairs wound healing by its effect on the T cell-mediated immune system, and that this system may also be involved in regulation of the reparative process because its absence leads to tougher wounds.
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Authors | D J Corless, J Holland, C Wastell |
Journal | The British journal of surgery
(Br J Surg)
Vol. 82
Issue 3
Pg. 368-70
(Mar 1995)
ISSN: 0007-1323 [Print] England |
PMID | 7796012
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Immunocompetence
- Lymphopenia
- Male
- Models, Biological
- Powders
- Rats
- Rats, Nude
- Starch
- Wound Healing
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