[Neoadjuvant chemotherapy of liver tumors metastasized by sigmoid colon cancer: a case report of CDDP/5-FU intraarterial infusion therapy followed by hepatectomy].

Abstract

A case of liver tumors metastasized by Sigmoid colon cancer was treated with intrahepatic arterial infusion of CDDP (10 mg) and 5-FU (250 mg) via subcutaneously implanted reservoir. After 20 administrations of CDDP and 5-FU, the tumors in the right lobe of the liver disappeared, but those in the left lobe remained. Therefore left hepatectomy was carried out. Six months after the hepatectomy, a nodule recurrence was disclosed in the right lobe of the liver. With re-elevated serum CEA level, subsequent intrahepatic arterial infusion of CDDP and 5-FU the nodule size reduced with normalization of the serum CEA level.

• Authors: F Yamashita, M Tanaka, S Yutani, M Shimada, T Kusaba, S Kuroki, J Inoue, O Katoh, K Sasatomi, K Tanikawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Issue 7 Pg. 949-52 (Jun 1995) ISSN: 0385-0684 [Print] Japan
• PMID: 7794002 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Cisplatin
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Fluorouracil (administration & dosage)
• Hepatectomy
• Hepatic Artery
• Humans
• Infusion Pumps, Implantable
• Infusions, Intra-Arterial
• Liver Neoplasms (drug therapy, secondary, surgery)
• Male
• Sigmoid Neoplasms (pathology)