Prophylactic oral ibuprofen or ibuprofen-codeine versus placebo for postoperative pain after primary hip arthroplasty.

Abstract

The postoperative analgesic effect of ibuprofen was compared with a combination of ibuprofen and codeine versus placebo. The study was prospective, randomized, double blind with 123 consecutive hip arthroplasty operations. All the patients received oral diazepam as premedication and spinal anaesthesia with bupivacaine 5 mg/ml 3-4 ml. Postoperatively, when the spinal anaesthesia started to wear off, the patients were randomly assigned to one of three groups; the ibuprofen group (n = 48) received 800 mg of ibuprofen orally. The ibuprofen/codeine group (IC, n = 48) received 800 mg of ibuprofen combined with 60 mg of codeine. The placebo group (P, n = 25), received oral placebo medication. The patients were observed for the need of additional opioid (e.g. ketobemidone), pain score (verbal and VAS), bleeding and side effects for five hours. The patients in the placebo group (P) had significantly higher pain scores (P < 0.05) compared with the two other groups after 2 and 4 hours, with no significant differences after 1, 3 and 5 hours. The P group also received 45% more opioids (P < 0.001) compared with the two other groups during the same period. No significant differences in bleeding or side-effects were observed between the groups. There were no significant differences between the ibuprofen group and the ibuprofen/codeine group. We conclude that a prophylactic dose of 800 mg ibuprofen orally has an opioid sparing effect with a tendency of less pain experience during the first hours after hip arthroplasty.

• Authors: V Dahl, J C Raeder, S Drøsdal, O Wathne, J Brynildsrud
• Journal: Acta anaesthesiologica Scandinavica (Acta Anaesthesiol Scand) Vol. 39 Issue 3 Pg. 323-6 (Apr 1995) ISSN: 0001-5172 [Print] England
• PMID: 7793209 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Codeine
• Ibuprofen

Topics

• Administration, Oral
• Aged
• Codeine (administration & dosage)
• Double-Blind Method
• Drug Therapy, Combination
• Hip Prosthesis
• Humans
• Ibuprofen (administration & dosage, therapeutic use)
• Middle Aged
• Pain, Postoperative (drug therapy)
• Prospective Studies