Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets.

Abstract

Elyzo 25% Dentalgel (EDG) which is developed for use in the treatment of periodontitis is a suspension of metronidazole benzoate (40%) in a mixture of glyceryl mono-oleate (GMO) and triglyceride (sesame oil). Metronidazole can be detected in the periodontal pockets 24-36 h after application. The aim of the present study was to estimate the period of time that the gel matrix persists on periodontal pockets after 1 application of EDG. 12 patients were included in the study. From each patient, 1 sample was taken before and immediately after, and 1, 2, 3, 4, 5, 6, 8, 12 and 24 h after application. Subgingival scaling followed by absorption of gingival crevicular fluid with filter paper was used for sampling. The sampling unit was 1 tooth. Each sample was assayed for the amount of GMO and oleic acid (a degradation product of GMO) by means of high-performance liquid chromatography (HPLC) with UV detection. To allow determination of the GMO dose applied into the pockets and to estimate the recovery rate of the sampling method, 1 tooth in each patient was selected for sampling as soon as the gel had set, i.e., about 10 min after application. Only in 1 patient was a detectable amount of GMO within the pocket revealed 24 h after application. This amount was approximately 0.5% of the mean GMO dose applied around 1 tooth. GMO was found no longer than 12 h in the remaining patients.

• Authors: K Stoltze
• Journal: Journal of clinical periodontology (J Clin Periodontol) Vol. 22 Issue 3 Pg. 185-7 (Mar 1995) ISSN: 0303-6979 [Print] United States
• PMID: 7790523 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Elyzol Dentalgel
• Gels
• Glycerides
• Oleic Acids
• Metronidazole
• Oleic Acid
• Sesame Oil
• monoolein

Topics

• Absorption
• Adult
• Chromatography, High Pressure Liquid
• Dental Scaling
• Female
• Gels
• Gingival Crevicular Fluid (chemistry, metabolism)
• Glycerides (administration & dosage, analysis, pharmacokinetics)
• Humans
• Male
• Metronidazole (administration & dosage, analogs & derivatives, analysis, pharmacokinetics)
• Middle Aged
• Oleic Acid
• Oleic Acids (analysis)
• Periodontal Pocket (metabolism)
• Periodontitis (drug therapy)
• Sesame Oil (administration & dosage, analysis, pharmacokinetics)
• Time Factors