3-(3-Hydroxyphenyl)-N-(1-propyl)piperidine elicits convulsant effects in mice.

Abstract

1. The behaviour and EEG effects of the dopamine and sigma (sigma) ligands (+) 3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)3-PPP) were studied in mice. 2. (+) 3-PPP dose-dependently (60-100 mg/kg i.p.) produced behavioural and electrical tonic-clonic seizures. 3. The incidence of the tonic seizures elicited by 100 mg/kg of the drug was significantly (P < 0.05) prevented by spiperone (0.5 mg/kg i.p.) and haloperidol (0.5 mg/kg i.p.). 4. The results show an influence on the behavioural and electrical threshold of convulsions by (+) 3-PPP depending on a prevalent interference on dopamine receptors.

• Authors: S Pieretti, A Di Giannuario, S Sagratella
• Journal: General pharmacology (Gen Pharmacol) Vol. 26 Issue 3 Pg. 623-6 (May 1995) ISSN: 0306-3623 [Print] England
• PMID: 7789737 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• Convulsants
• Dopamine Agonists
• Dopamine Antagonists
• Piperidines
• Receptors, sigma
• preclamol

Topics

• Animals
• Antipsychotic Agents (pharmacology)
• Behavior, Animal (drug effects)
• Convulsants (antagonists & inhibitors, pharmacology)
• Dopamine Agonists (pharmacology)
• Dopamine Antagonists (pharmacology)
• Electric Stimulation
• Electroencephalography (drug effects)
• Male
• Mice
• Piperidines (antagonists & inhibitors, pharmacology)
• Receptors, sigma (metabolism)
• Seizures (chemically induced, psychology)
• Stereoisomerism