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[Abuse potential during use and withdrawal psychosis after treatment with the hypnotic zolpidem (Stilnoct)].

Abstract
Three cases are presented. Withdrawal symptoms and ultimately psychosis developed in two cases following cessation of the hypno-sedative zolpidem. Two cases involve dependence upon and abuse of the drug; in one, a well-known alcoholic, it was abused in combination with alcohol, the other had prior well-known dependence on sedative hypnotics. One patient had chronic dysphoria and one encephalopatia toxica. Adverse effects such as withdrawal symptoms, dependence and abuse have not previously been reported in relation to zolpidem. Chemically unrelated to benzodiazepines, zolpidem is thought to have fewer adverse effects, but shares a pharmacokinetic profile with the benzodiazepine triazolam. It is advised that normal criteria for the prescription of benzodiazepines also be used when prescribing non-benzodiazepine sedatives and hypnotics, as they act upon the same receptor, namely the benzodiazepine-GABA-chloride complex.
AuthorsT G Bruun
JournalUgeskrift for laeger (Ugeskr Laeger) Vol. 155 Issue 35 Pg. 2711-3 (Aug 30 1993) ISSN: 0041-5782 [Print] Denmark
Vernacular TitleMisbrugspotentiale under brug og abstinenspsykose efter behandling med sovemidlet zolpidem (Stilnoct).
PMID7786333 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Hypnotics and Sedatives
  • Pyridines
  • Zolpidem
Topics
  • Adult
  • Female
  • Humans
  • Hypnotics and Sedatives (adverse effects)
  • Male
  • Middle Aged
  • Psychoses, Substance-Induced (etiology)
  • Pyridines (adverse effects)
  • Substance Withdrawal Syndrome (diagnosis)
  • Zolpidem

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