HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Endoscopically controlled trial of alginate and antacid in reflux oesophagitis.

Abstract
A double-blind crossover trial of Gaviscon (alginate/alginic acid plus antacid) versus standard antacid is reported in 20 patients with symptomatic hiatus hernia. Gaviscon was well tolerated but clinical improvement was equally good with antacid in this short-term (six-week study). At the beginning, endoscopic evidence of erosions or "oesophagitis" was common (in 12 of the 20 subjects). Oesophagoscopic evidence of improvement was seen in 50% of patients with both types of medication over a three-week period, compared with subjective improvement in 84%. Long-term studies are necessary to establish the natural history of peptic lesions of the oesophagus and their treatment, whether conservative or surgical.
AuthorsB A Scobie
JournalThe Medical journal of Australia (Med J Aust) Vol. 1 Issue 17 Pg. 627-8 (Apr 24 1976) ISSN: 0025-729X [Print] Australia
PMID778564 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Alginates
  • Antacids
  • Drug Combinations
Topics
  • Adult
  • Aged
  • Alginates (therapeutic use)
  • Antacids (therapeutic use)
  • Clinical Trials as Topic
  • Drug Combinations
  • Esophagitis, Peptic (diagnosis, drug therapy, etiology)
  • Esophagoscopy
  • Female
  • Hernia, Diaphragmatic (drug therapy)
  • Hernia, Hiatal (complications, drug therapy)
  • Humans
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: