Microsatellite D21S210 (GT-12) allele frequencies in sporadic Alzheimer's disease.

Abstract

Four disease-causing mutations have so far been described in the amyloid precursor protein gene on chromosome 21 in familial early-onset Alzheimer's disease. Linkage analysis with a fourteen-allele microsatellite at D21S210 named GT-12 has proven useful in the elucidation of amyloid precursor protein gene involvement in Alzheimer's disease families, as it is closely linked to the gene. Most cases of Alzheimer's disease are thought to be sporadic and not familial. However, evidence from earlier studies suggests an important genetic contribution also in sporadic cases, where gene-environment interaction may contribute to the disease. We have determined frequencies of the GT-12 alleles in 78 Swedish and 49 British sporadic Alzheimer's disease cases and 104 healthy elderly control subjects, to investigate if the disease associates with a particular genotype in GT-12. However, no differences in allele frequencies were observed between any of the groups.

• Authors: L Lannfelt, L Lilius, M Viitanen, H Houlden, M Rossor, J Hardy, B Winblad, H Basun
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 91 Issue 2 Pg. 145-8 (Feb 1995) ISSN: 0001-6314 [Print] Denmark
• PMID: 7785426 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Protein Precursor
• DNA, Satellite

Topics

• Aged
• Aged, 80 and over
• Alleles
• Alzheimer Disease (diagnosis, genetics)
• Amyloid beta-Protein Precursor (genetics)
• Chromosomes, Human, Pair 21
• DNA, Satellite (genetics)
• Female
• Gene Frequency
• Humans
• Male
• Middle Aged
• Models, Genetic
• Polymerase Chain Reaction
• Reference Values
• Sweden
• United Kingdom