Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy.

Abstract

PURPOSE:

To examine the use of O-methoxy poly(ethylene)glycol-O'-succinyl-N-epsilon-poly(L-lysyl) gadolinium diethylenetriaminepentaacetic acid (MPEG-PL-Gd-DTPA) as a potential magnetic resonance (MR) angiographic contrast agent for the detection of gastrointestinal (GI) bleeding.

MATERIALS AND METHODS:

MPEG-PL-Gd-DTPA was used for blood pool enhancement, and MPEG-PL-technetium-99m DTPA was used for planar nuclear imaging studies. GI bleeding was tested in rats by controlled injection of contrast material-doped blood through a jejunostomy catheter. MR imaging was performed at 1.5 T.

RESULTS:

Ideal flip angle, used with a spoiled gradient-echo pulse sequence, was 40 degrees. The smallest amount of hemorrhage detected at MR imaging was 0.05 mL; at nuclear imaging it was 0.02 mL. With the superior spatial resolution of MR imaging, individual loops of contrast material-filled bowel were identified and bleeding points were pinpointed.

CONCLUSION:

GI hemorrhage can be easily detected at MR imaging if a long circulating macromolecular contrast agent is used to decrease the T1 of extravasated blood.

• Authors: H Gupta, R Weissleder, A A Bogdanov Jr, T J Brady
• Journal: Radiology (Radiology) Vol. 196 Issue 1 Pg. 239-44 (Jul 1995) ISSN: 0033-8419 [Print] United States
• PMID: 7784574 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• monomethoxypolyethylene glycol-polylysine-gadolinium DTPA
• technetium Tc 99m methoxypoly(ethylene)glycol-polylysyl-DTPA
• Polylysine
• Polyethylene Glycols
• Pentetic Acid
• Gadolinium DTPA
• Technetium Tc 99m Pentetate

Topics

• Animals
• Contrast Media
• Gadolinium DTPA
• Gastrointestinal Hemorrhage (diagnosis, diagnostic imaging)
• Magnetic Resonance Imaging
• Models, Structural
• Pentetic Acid (analogs & derivatives)
• Polyethylene Glycols
• Polylysine (analogs & derivatives)
• Radionuclide Imaging
• Rats
• Rats, Sprague-Dawley
• Technetium Tc 99m Pentetate (analogs & derivatives)