[19F-MR imaging of transplanted tumor: perfluorochemicals as a fluorine tumor imaging agent].

Abstract

PURPOSE:

The purpose of our study was to detect tumor selectively using 19F-magnetic resonance imaging (MRI) and to assess Fluosol-DA, a perfluorochemical emulsion, as a tumor imaging agent for 19F-MRI.

MATERIALS AND METHODS:

SCC VII cells were transplanted in the right leg of mice. After 6 days, Fluosol-DA was administrated intravenously (40 ml/kg). 19F-MR imaging was performed on a Bruker CSI Omega 2 at 4.7 Tesla using a homemade volume coil.

RESULTS:

In vitro, the concentration and 19F signal intensity of FDA showed a very high correlation (r = 0.9997). Detection on MRI was possible at a concentration of 2%. In vivo, images of 19F in SCC VII tumors were achieved in animals 2 days after the administration of FDA.

CONCLUSION:

Our study confirms the feasibility of 19F-MR in vivo imaging of tumors using the fluorine compound FDA.

• Authors: Y H Itoh, Y Kandori, M Takahashi, B Fritz-Zieroth, N Miyata
• Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica (Nihon Igaku Hoshasen Gakkai Zasshi) Vol. 55 Issue 5 Pg. 345-7 (Apr 1995) ISSN: 0048-0428 [Print] Japan
• PMID: 7784157 (Publication Type: English Abstract, Journal Article)

Chemical References

• Drug Combinations
• Fluorocarbons
• Hydroxyethyl Starch Derivatives
• glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination

Topics

• Animals
• Carcinoma, Squamous Cell (diagnosis)
• Drug Combinations
• Female
• Fluorocarbons
• Hydroxyethyl Starch Derivatives
• Magnetic Resonance Imaging
• Mice
• Mice, Inbred C3H
• Neoplasm Transplantation