Abstract | BACKGROUND: EXPERIMENTAL DESIGN:
Selenium-deficient and control rats were injected with phorone to deplete glutathione. Histologic assessment of liver and kidney injury was performed at 24 hours. In another experiment, glutathione depletion, lipid peroxidation, and liver injury were measured for 12 hours after phorone administration to determine their relationships with one another. In a final experiment, selenoproteins were correlated with protection against lipid peroxidation and liver necrosis. Selenium-deficient rats were injected with vehicle alone and with 5, 10, or 25 micrograms of selenium/kg. Twelve hours later, selenoproteins were measured in some of the rats, and phorone was injected into others. Liver injury and lipid peroxidation were assessed 6 hours after the phorone injection. RESULTS: CONCLUSIONS:
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Authors | R F Burk, K E Hill, J A Awad, J D Morrow, P R Lyons |
Journal | Laboratory investigation; a journal of technical methods and pathology
(Lab Invest)
Vol. 72
Issue 6
Pg. 723-30
(Jun 1995)
ISSN: 0023-6837 [Print] United States |
PMID | 7783430
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Ketones
- Lipid Peroxides
- Maleates
- Proteins
- Selenoprotein P
- Selenoproteins
- Methionine Sulfoximine
- Buthionine Sulfoximine
- phorone
- Dinoprost
- diethyl maleate
- Glutathione
- Selenium
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Topics |
- Animals
- Buthionine Sulfoximine
- Dinoprost
(analogs & derivatives, metabolism)
- Glutathione
(antagonists & inhibitors, deficiency, metabolism)
- Ketones
(pharmacology)
- Kidney
(drug effects, pathology)
- Lipid Peroxides
(metabolism)
- Liver
(drug effects, pathology)
- Male
- Maleates
(pharmacology)
- Methionine Sulfoximine
(analogs & derivatives, pharmacology)
- Necrosis
- Osmolar Concentration
- Proteins
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Selenium
(deficiency, pharmacology)
- Selenoprotein P
- Selenoproteins
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