Abstract | BACKGROUND: OBJECTIVES: RESULTS: Based on the three known cases of fatal liver failure associated with pemoline use, we calculated that a child receiving pemoline has a relative risk of development of fulminant liver failure of 45.3 (95% confidence interval, 4.1 to 510). This highly significant association (p < 0.001) suggests causation. CONCLUSIONS:
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Authors | M Berkovitch, E Pope, J Phillips, G Koren |
Journal | Clinical pharmacology and therapeutics
(Clin Pharmacol Ther)
Vol. 57
Issue 6
Pg. 696-8
(Jun 1995)
ISSN: 0009-9236 [Print] United States |
PMID | 7781270
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Adolescent
- Attention Deficit Disorder with Hyperactivity
(drug therapy)
- Fatal Outcome
- Hepatic Encephalopathy
(chemically induced)
- Humans
- Male
- Pemoline
(adverse effects, therapeutic use)
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