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Clinical effect of captopril on the formation and growth of cystine calculi.

Abstract
We determined the clinical efficacy of captopril for the prevention of new or stone growth in patients with homozygous cystinuria. Nine patients with a history of multiple cystine stones despite standard fluid and alkalization therapy received 50 mg. captopril, 3 times daily in addition to the standard therapy. Before treatment the rate of new stone formation or stone growth ranged from 0.7 to 2.0 events (mean 1.2) per patient-year for 1 to 3 years of observation (mean 1.9). During treatment the rate ranged from 0 to 3.0 events (mean 1.03) per patient-year for 0.5 to 6 years (mean 2.9). Although statistical significance was not evident for the group as a whole (p = 0.35), our findings suggest that captopril may be clinically efficacious in at least some patients with difficult to control cystinuria. Recommendations regarding its indications in this setting are made.
AuthorsT D Cohen, S B Streem, P Hall
JournalThe Journal of urology (J Urol) Vol. 154 Issue 1 Pg. 164-6 (Jul 1995) ISSN: 0022-5347 [Print] United States
PMID7776415 (Publication Type: Journal Article)
Chemical References
  • Citrates
  • Citric Acid
  • Cystine
  • Sodium Bicarbonate
  • Captopril
Topics
  • Adult
  • Aged
  • Captopril (therapeutic use)
  • Citrates (therapeutic use)
  • Citric Acid
  • Cystine (analysis)
  • Cystinuria (complications, drug therapy, urine)
  • Female
  • Fluid Therapy
  • Follow-Up Studies
  • Humans
  • Kidney Calculi (chemistry, etiology, prevention & control)
  • Male
  • Middle Aged
  • Sodium Bicarbonate (therapeutic use)
  • Treatment Outcome

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