Abstract |
We determined the clinical efficacy of captopril for the prevention of new or stone growth in patients with homozygous cystinuria. Nine patients with a history of multiple cystine stones despite standard fluid and alkalization therapy received 50 mg. captopril, 3 times daily in addition to the standard therapy. Before treatment the rate of new stone formation or stone growth ranged from 0.7 to 2.0 events (mean 1.2) per patient-year for 1 to 3 years of observation (mean 1.9). During treatment the rate ranged from 0 to 3.0 events (mean 1.03) per patient-year for 0.5 to 6 years (mean 2.9). Although statistical significance was not evident for the group as a whole (p = 0.35), our findings suggest that captopril may be clinically efficacious in at least some patients with difficult to control cystinuria. Recommendations regarding its indications in this setting are made.
|
Authors | T D Cohen, S B Streem, P Hall |
Journal | The Journal of urology
(J Urol)
Vol. 154
Issue 1
Pg. 164-6
(Jul 1995)
ISSN: 0022-5347 [Print] United States |
PMID | 7776415
(Publication Type: Journal Article)
|
Chemical References |
- Citrates
- Citric Acid
- Cystine
- Sodium Bicarbonate
- Captopril
|
Topics |
- Adult
- Aged
- Captopril
(therapeutic use)
- Citrates
(therapeutic use)
- Citric Acid
- Cystine
(analysis)
- Cystinuria
(complications, drug therapy, urine)
- Female
- Fluid Therapy
- Follow-Up Studies
- Humans
- Kidney Calculi
(chemistry, etiology, prevention & control)
- Male
- Middle Aged
- Sodium Bicarbonate
(therapeutic use)
- Treatment Outcome
|