Pharmaceutical development of a parenteral formulation of the novel anti-tumor agent carzelesin (U-80,244).

Abstract

The aim of this study was to design a parenteral dosage form for the investigational cytotoxic drug carzelesin. A stable formulation in PET (Polyethylene glycol 400/absolute ethanol/Tween 80, 6:3:1, v/v/v) was developed. The prototype, containing 0.50 mg carzelesin in 2.0 ml PET formulation, was found to be the optimal formulation in terms of solubility, stability and dosage requirements in phase I clinical trials. Quality control of the formulation showed that the pharmaceutical preparation of carzelesin in PET is not negatively influenced by the manufacturing process. Shelf life studies demonstrated that the formulation is stable for at least 1 year, when stored at -30 degrees C in the dark. In addition, the stability of carzelesin in the PET formulation is discussed as a function of temperature, additives and after dilution in infusion fluids.

• Authors: J D Jonkman-de Vries, M J de Graaff-Teulen, R E Henrar, J J Kettenes-van den Bosch, A Bult, J H Beijnen
• Journal: Investigational new drugs (Invest New Drugs) Vol. 12 Issue 4 Pg. 303-14 ( 1994) ISSN: 0167-6997 [Print] United States
• PMID: 7775131 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Benzofurans
• Duocarmycins
• Indoles
• Polysorbates
• Ethanol
• Polyethylene Glycols
• carzelesin

Topics

• Antineoplastic Agents (administration & dosage, analysis, chemistry)
• Benzofurans (administration & dosage, analysis, chemistry)
• Chemistry, Pharmaceutical
• Chromatography, High Pressure Liquid
• Drug Stability
• Duocarmycins
• Ethanol
• Indoles (administration & dosage, analysis, chemistry)
• Infusions, Parenteral
• Magnetic Resonance Spectroscopy
• Polyethylene Glycols
• Polysorbates
• Quality Control
• Spectrometry, Mass, Fast Atom Bombardment
• Spectrophotometry