[The effect of cerebrocrast on the microcirculation in acute transient cerebral ischemia].

Abstract

In experiments on rats with cerebral ischemia (30-min occlusion of carotid arteries), the novel calcium antagonist Cerebrocrast (0.4 microgram.kg-1.min-1 i.v. for 15 min) was found to provide the functional maintenance of the parietal cerebral bed in the postischemic period by improving cerebral hemodynamics, reducing the number of highly narrowed capillaries. The agent prevented the erythrocytic accumulation of lipid peroxidation (LPO) products (diene conjugates and Schiff bases) in the intra- and postischemic periods, promoted the maintenance of viscoelastic properties during LPO activation.

• Authors: T M Plotnikova, T G Bazhenova, M B Plotnikov, A S Saratikov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 Mar-Apr Vol. 58 Issue 2 Pg. 27-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vliianie tserebrokrasta na mikrotsirkuliatsiiu pri ostroĭ tranzitornoĭ ishemii mozga.
• PMID: 7773083 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Calcium Channel Blockers
• Dihydropyridines
• Vasodilator Agents
• 2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine

Topics

• Acute Disease
• Animals
• Calcium Channel Blockers (pharmacology, therapeutic use)
• Cerebrovascular Circulation (drug effects, physiology)
• Dihydropyridines (pharmacology, therapeutic use)
• Drug Evaluation, Preclinical
• Ischemic Attack, Transient (metabolism, physiopathology, prevention & control)
• Lipid Peroxidation (drug effects)
• Male
• Microcirculation (drug effects, physiology)
• Rats
• Vasodilator Agents (pharmacology, therapeutic use)