[The interaction of dopamine and opioid receptors in the re-establishing of an amnesic and forgotten memory trace by quinpirole].

Abstract

The present study evaluated the contribution of delta and kappa opioid receptors to the dopamine-mediated reestablishment of an amnestic and forgotten memory trace. Using passive avoidance as a memory index, the pretraining injection of leukephalin was determined to enhance the efficiency of quinpirole, a selective dopamine D-2 receptor agonist, to reactivate the memory retrieval in amnesia and forgetfulness. In contrast, pretreatment with dynorphin attenuated the retrieval by enhancing the effect of the pretesting injection of quinpirole in amnesia. Quinpirole was found to be more effective in attenuating amnesia than forgetfulness.

• Authors: R Iu Il'iuchenok, N I Dubrovina
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 1995 Mar-Apr Vol. 58 Issue 2 Pg. 16-9 ISSN: 0869-2092 [Print] Russia (Federation)
• Vernacular Title: Vzaimodeĭstvie dofaminovykh i opioidnykh retseptorov pri vosstanovlenii amnezirovannogo i zabytogo sleda pamiati kvinpirolom.
• PMID: 7773079 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Dopamine Agonists
• Ergolines
• Receptors, Dopamine
• Receptors, Opioid
• Quinpirole
• Enkephalin, Leucine
• Dynorphins

Topics

• Amnesia (drug therapy, etiology)
• Animals
• Avoidance Learning (drug effects)
• Conditioning, Classical (drug effects)
• Dopamine Agonists (therapeutic use)
• Drug Evaluation, Preclinical
• Drug Interactions
• Dynorphins (pharmacology)
• Enkephalin, Leucine (pharmacology)
• Ergolines (therapeutic use)
• Male
• Memory Disorders (drug therapy, etiology)
• Mice
• Mice, Inbred BALB C
• Quinpirole
• Reaction Time (drug effects)
• Receptors, Dopamine (drug effects)
• Receptors, Opioid (drug effects)
• Time Factors