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Topical cyclosporin in oral lichen planus: a controlled, randomized, prospective trial.

Abstract
The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste (triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement in disease activity. Contradictory results from earlier reports are discussed.
AuthorsP Sieg, H Von Domarus, V Von Zitzewitz, H Iven, L Färber
JournalThe British journal of dermatology (Br J Dermatol) Vol. 132 Issue 5 Pg. 790-4 (May 1995) ISSN: 0007-0963 [Print] England
PMID7772487 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Review)
Chemical References
  • Cyclosporine
  • Triamcinolone Acetonide
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Cyclosporine (administration & dosage)
  • Female
  • Humans
  • Lichen Planus (drug therapy)
  • Male
  • Middle Aged
  • Mouth Diseases (drug therapy)
  • Prospective Studies
  • Triamcinolone Acetonide (therapeutic use)

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