Abstract |
The published studies of topical cyclosporin (CyA) therapy in chronic oral lichen planus (OLP) have shown conflicting results. We report an investigator-blinded study of 13 patients with OLP, who were randomly assigned to treatment with CyA (500 mg as a swish-and-spit medication for 5 min three times daily) or a corticosteroid oral paste ( triamcinolone acetonide). The duration of treatment was 6 weeks. Thereafter, patients on corticosteroid therapy were treated with CyA. Only slight, transient clinical improvement was observed in both groups after 6 weeks of treatment, compared with baseline. No significant differences could be demonstrated between the two groups. CyA therapy following corticosteroid treatment did not produce any further clinical improvement. During follow-up of the disease for up to 1 year after treatment, neither the CyA nor the corticosteroid group exhibited long-term improvement in disease activity. Contradictory results from earlier reports are discussed.
|
Authors | P Sieg, H Von Domarus, V Von Zitzewitz, H Iven, L Färber |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 132
Issue 5
Pg. 790-4
(May 1995)
ISSN: 0007-0963 [Print] England |
PMID | 7772487
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Review)
|
Chemical References |
- Cyclosporine
- Triamcinolone Acetonide
|
Topics |
- Administration, Topical
- Adult
- Aged
- Cyclosporine
(administration & dosage)
- Female
- Humans
- Lichen Planus
(drug therapy)
- Male
- Middle Aged
- Mouth Diseases
(drug therapy)
- Prospective Studies
- Triamcinolone Acetonide
(therapeutic use)
|