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Improved lung function by urokinase infusion in canine lung transplantation using non-heart-beating donors.

Abstract
We evaluated the effect of urokinase on pulmonary microthrombi formation of the donor lung using a canine cadaver left lung allotransplantation model. Donor animals were sacrificed with an intravenous injection of potassium chloride without heparinization and were divided into three groups. In group 1 (n = 6), cadavers were left at room temperature for 1 hour, and lung retrieval was then performed after flushing the lung block with low potassium-dextran-glucose solution. Donor lungs were stored for 3 hours at 8 degrees C. In group 2 (n = 6), donor lungs were treated as in group 1 except that the cadavers were left at room temperature for 2 hours instead of 1 hour before lung retrieval. In group 3 (n = 6), donor lungs were treated as in group 2 except that high-dose urokinase (120,000 IU) was injected into the main pulmonary artery after flushing with low-potassium-dextrose-glucose solution. In all groups after left lung transplantation, the right pulmonary artery was ligated, and recipient animals were followed up for 6 hours after reperfusion. The fibrin degradation product level in the donor lung tissue was also measured. All recipient animals in group 1 survived the 6-hour observation period with excellent gas exchange and stable hemodynamics. Group 3 had significantly better gas exchange than group 2 and similar cardiopulmonary function as group 1. The fibrin degradation product level in the donor lungs before transplantation was significantly higher in group 3 than in group 2.(ABSTRACT TRUNCATED AT 250 WORDS)
AuthorsY Umemori, H Date, K Uno, M Aoe, A Ando, N Shimizu
JournalThe Annals of thoracic surgery (Ann Thorac Surg) Vol. 59 Issue 6 Pg. 1513-8 (Jun 1995) ISSN: 0003-4975 [Print] Netherlands
PMID7771833 (Publication Type: Journal Article)
Chemical References
  • Fibrin Fibrinogen Degradation Products
  • Urokinase-Type Plasminogen Activator
Topics
  • Animals
  • Disease Models, Animal
  • Dogs
  • Fibrin Fibrinogen Degradation Products (analysis)
  • Injections, Intra-Arterial
  • Lung Transplantation (adverse effects, methods)
  • Pulmonary Artery
  • Pulmonary Embolism (drug therapy)
  • Pulmonary Gas Exchange
  • Tissue and Organ Procurement (methods)
  • Transplantation, Homologous (methods)
  • Urokinase-Type Plasminogen Activator (therapeutic use)

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